Altered immune environment in peritoneal endometriotic lesions: relationship to lesion appearance

Peritoneal endometriotic lesions differentially express a haptoglobin-like gene.

A unique glycoprotein, called endometriosis protein-I (ENDO-I), has previously been shown to be synthesized and secreted by rat and human endometriotic explants. Furthermore, the N-terminal amino acid sequence analysis showed that ENDO-I shares homology with haptoglobin. The present study was designed to determine this sequence of ENDO-I cDNA from human peritoneal endometriotic lesions and to d...

High-Throughput Sequencing Approach Uncovers the miRNome of Peritoneal Endometriotic Lesions and Adjacent Healthy Tissues

Accumulating data have shown the involvement of microRNAs (miRNAs) in endometriosis pathogenesis. In this study, we used a novel approach to determine the endometriotic lesion-specific miRNAs by high-throughput small RNA sequencing of paired samples of peritoneal endometriotic lesions and matched healthy surrounding tissues together with eutopic endometria of the same patients. We found five mi...

Hormonal Contraceptive Use and the Prevalence of Endometriotic Lesions at Different Regions within the Peritoneal Cavity

Endometriosis is an estrogen-dependent disease that can lead to chronic pain and subfertility. Endometriotic lesions found in different locations are heterogeneous and may represent a collection of related but distinct conditions. Whether there is a relationship between hormonal contraceptive (HC) use and endometriosis is still controversial. The purpose of this study was to determine whether H...

The Local Immune Mechanisms Involved in the Formation of Endometriotic Lesions

Laparoscopic Appearance of Peritoneal Tuberculosis

A 37-year-old Indian male with history of daily alcohol use presented to the hospital with abdominal pain and distention for 2 weeks. Abdominal and pelvic computed tomography showed ascites, peritoneal thickening with omental infiltration. Chest xray was normal, and sputum analysis was negative for infection. Ascitic fluid analysis showed a serum ascites albumin gradient of 0.8 g/dL, total prot...